Should Esketamine be used on its own?

Esketamine is primarily used in conjunction with an oral antidepressant when treating depression in individuals, particularly those with treatment-resistant depression. This combination is important because while Esketamine can provide rapid relief from depressive symptoms, it is not typically considered sufficient as a standalone treatment. The use of an oral antidepressant helps to enhance its efficacy and provides a more comprehensive approach to managing the disorder.

Furthermore, using Esketamine in combination with an oral antidepressant allows for a more robust framework for monitoring and managing the overall treatment, addressing both immediate symptoms and longer-term management of depression. This collaborative approach is in line with best practices supported by clinical guidelines and ensures that patients receive the most effective care possible.

Other options suggest that Esketamine can be effective on its own or that it has no interactions, which does not take into account the need for a more thorough treatment strategy that includes ongoing management through oral medication. Additionally, the notion that it should never be mixed with other medications overlooks the clinical evidence supporting its use alongside prescribed antidepressants to achieve better outcomes.